PREPRINTS:
Wang T, Soundararajan A, Rabinowitz J, Jaiswal A, Osborne T, Pattabiraman PP. Targeting sterol regulatory element binding proteins (SREBPs) activation lowers intraocular pressure by halting its mechanosensing function in the trabecular meshwork. bioRxiv 2023.02.05.527136; doi: https://doi.org/10.1101/2023.02.05.527136
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PEER-REVIEWED RESEARCH ARTICLES:
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Pattabiraman, P.P.; Feinstein, V.; Beit-Yannai, E. Profiling the miRNA from Exosomes of Non-Pigmented Ciliary Epithelium-Derived Identifies Key Gene Targets Relevant to Primary Open-Angle Glaucoma. Antioxidants 2023, 12, 405. https://doi.org/10.3390/antiox12020405
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Wang T, Pattabiraman PP. Analysis of Lipid Contents in Human Trabecular Meshwork Cells by Multiple Reaction Monitoring (MRM) Profiling Lipidomics. Methods Mol Biol. 2023;2625:291-298. doi: 10.1007/978-1-0716-2966-6_24. PMID: 36653651.
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Soundararajan A*, Wang T*, Sundararajan R, Wijeratne A, Mosley A, Harvey FC, Bhattacharya S, Pattabiraman PP. Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions. Front Cell Dev Biol. 2022 Sep 13;10:874828. doi: 10.3389/fcell.2022.874828. PMID: 36176278; PMCID: PMC9513235.
*equal contribution
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Soundararajan A, Wang T, Ghag SA, Kang MH, Pattabiraman PP. Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork. J Cell Physiol. 2022 May 14. doi: 10.1002/jcp.30769. Epub ahead of print. PMID: 35567755.
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Soundararajan A*, Ghag SA*, Vuda SS, Wang T, Pattabiraman PP. Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells. 2021 Oct 24;10(11). doi: 10.3390/cells10112864. PMID: 34831087. *equal contribution
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Toris CB, Pattabiraman PP, Tye G, Samuelson TW, Rhee DJ. Outflow Facility Effects of Three Schlemm Canal MIGS. Ophthalmology Glaucoma, 2020 3(2) 114-121.
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BOOK CHAPTERS:
Padmanabhan PP, and Soundararajan A. Rho kinase inhibition – A therapeutic intervention for glaucoma. Glaucoma Toward Solving the Problem 2020 to 2022. Edited By Knepper and Samples: Kugler 2020
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Toris C.B., Tye G, Pattabiraman P. Changes in Parameters of Aqueous Humor Dynamics Throughout Life. In: Guidoboni G., Harris A., Sacco R. (eds) Ocular Fluid Dynamics. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. (2019) p. 161-190
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CONFERENCE ABSTRACTS:
Sai Supriya Vuda1, Haarika Reddy, Jeffrey Rabinowitz, Padmanabhan P Pattabiraman; Cathepsin K, a lysosomal protease, modulates expression and availability of transforming growth factor β2 (TGFβ2) and extracellular matrix remodeling in trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3429. (1ARVO/NEI TRAVEL AWARD WINNER)
Jeffrey Rabinowitz, Haarika Reddy, Padmanabhan P Pattabiraman; Clusterin acts as an endogenous statin by controlling the expression and nuclear translocation of sterol regulatory-element binding protein (SREBP) in trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3462.
Avinash Soundararajan, Joshua William Buzzard, Haarika Reddy, Min Hyung Kang, Douglas J Rhee, Padmanabhan P Pattabiraman; Regulation and role of clusterin, a secretory chaperone protein, on intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3208. (ARVO Talk)
Ting Wang, Jeffery Rabinowitz, Haarika Reddy, Cristina Ferreira, Padmanabhan Pattabiraman. Clusterin modulates lipid biogenesis in trabecular meshwork. American Society for Cell Biology (Virtual Meeting) December 2020
Sachin Anil Ghag, Padmanabhan Pattabiraman. Dexamethasone Inhibits Canonical Notch Signaling Pathway in Trabecular Meshwork. American Society for Cell Biology (Virtual Meeting) December 2020
C Singh, D Jusufbegovic, J Lind, P Pattabiraman. Glaucoma and Diabetes: A Sweet Connection. Proceedings of IMPRS, 2020
Sachin Anil Ghag1, Padmanabhan P Pattabiraman; Role of Notch Signaling Pathway in Steroid Induced Glaucoma. Invest. Ophthalmol. Vis. Sci. 2021;62(8):492. (1ARVO/NEI TRAVEL AWARD WINNER)
Ting Wang1, Jeffrey Rabinowitz, Padmanabhan P Pattabiraman; Inactivation of the Transcription Factor Sterol Regulatory Element Binding Protein (SREBP) Lowers Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 2021;62(8):476. (1ARVO/NEI TRAVEL AWARD WINNER)
Avinash Soundararajan1, Padmanabhan P Pattabiraman; Mechanistic Role of Clusterin in Extracellular Matrix remodeling and Intraocular Pressure Homeostasis. Invest. Ophthalmol. Vis. Sci. 2021;62(8):475. (1ARVO/NEI TRAVEL AWARD WINNER)
Chevy Singh, Avinash Soundararajan, Denis Jusufbegovic, John Lind, Padmanabhan P Pattabiraman; Alterations in Gene Expression of Human Trabecular Meshwork Cells in Response to Hyperglycemic Conditions. Invest. Ophthalmol. Vis. Sci. 2021;62(8):480.
Padmanabhan P Pattabiraman, Avinash Soundararajan, Ting Wang, Aruna Wijeratne, Amber Mosely; Mechanical Stretch Increases Cholesterol Biosynthesis in Human Trabecular Meshwork. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1639.
Sai Supriya Vuda1, Sachin Anil Ghag, Padmanabhan P Pattabiraman; Cathepsin K Activity in Trabecular Meshwork Outflow Pathway Regulates Intraocular Pressure Homeostasis. Invest. Ophthalmol. Vis. Sci. 2021;62(8):477. (1ARVO/NEI TRAVEL AWARD WINNER)
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*Padmanabhan P Pattabiraman, Ting Wang. Significance of sterol regulatory element-binding proteins (SREBPs) activation in intraocular pressure homeostasis. Mar 1-4 20220. Deuel Conference on Lipids. Monterey CA.
*Wang, Ting, and Padmanabhan Pattabiraman. "Trabecular Meshwork Cholesterol Levels Regulate Actin Polymerization and Tunneling Nanotubes." FASEB journal: official publication of the Federation of American Societies for Experimental Biology 36 (2022).
Padmanabhan Pattabiraman and Ting Wang.“NOVEL ROLE OF CATHEPSIN K IN THE REGULATION OF INTRAOCULAR PRESSURE BY MODULATING ACTIN POLYMERIZATION AND EXTRACELLULAR MATRIX REMODELING”. The extracellular matrix pharmacology Congress 2022. Copenhagen, Denmark.
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Ting Wang, Padmanabhan P Pattabiraman; Cholesterol regulates actin polymerization in trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3292 – A0392.
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Padmanabhan P Pattabiraman, Avinash Soundararajan; Loss of cathepsin K function in trabecular meshwork induces actin polymerization and apoptosis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):806.
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Avinash Soundararajan, Padmanabhan P Pattabiraman; Clusterin modulates IOP homeostasis by regulating the actin cytoskeleton and attenuating profibrotic responses in TM. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2648.
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